We did not identify any benefits associated with use of a lower INR range. All of them suggested that DOACs are cost-effective relative to VKA.100,104-116. Continued Treating DVT at Home. The outcomes were measured in both groups immediately at the end of the extended-duration treatment. Therefore, it was not possible to completely rule out a small difference between the alternatives on such outcomes. We estimated an annualized risk for major bleeding of 2.1%, assuming a risk for major bleeding close to 0 after anticoagulant discontinuation. doi: https://doi.org/10.1182/bloodadvances.2020001830. Available at: Clinical and safety outcomes associated with treatment of acute venous thromboembolism: a systematic review and meta-analysis, Comparison of the novel oral anticoagulants apixaban, dabigatran, edoxaban, and rivaroxaban in the initial and long-term treatment and prevention of venous thromboembolism: systematic review and network meta-analysis, Non-vitamin K oral anticoagulants in patients with pulmonary embolism: a systematic review and meta-analysis of the literature, Direct oral anticoagulants for the treatment of unprovoked venous thromboembolism: a meta-analysis of randomised controlled trials, Efficacy and safety of novel oral anticoagulants for treatment of acute venous thromboembolism: direct and adjusted indirect meta-analysis of randomised controlled trials, Comparison of dabigatran vs. warfarin in acute venous thromboemboly: systematic review, Direct oral anticoagulants in the treatment of venous thromboembolism, with a focus on patients with pulmonary embolism: an evidence-based review, Direct oral anticoagulants in the treatment of acute venous thromboembolism: a systematic review and meta-analysis, New oral anticoagulants in the treatment of acute venous thromboembolism - a systematic review with indirect comparisons [published correction appears in Vasa. The evidence-based guidelines from the American Society of Hematology (ASH) included 28 Plasminogen activator Italian multicenter study 2, Streptokinase and heparin in the treatment of pulmonary embolism: a randomized comparison, Six-month echocardiographic study in patients with submassive pulmonary embolism and right ventricle dysfunction: comparison of thrombolysis with heparin, Alteplase versus heparin in acute pulmonary embolism: randomised trial assessing right-ventricular function and pulmonary perfusion, Urokinase pulmonary embolism trial. However, they may help to select patients at low risk for complications. There were significant subgroup effects with the different antithrombotic interventions on DVT outcome. Other variables that may be important for the individual patient include whether the medication must be taken with food, preference for once-daily vs twice-daily dosing, the need to use a pill box, or the need to crush tablets prior to administration. Adapted from Kearon et al237 and Konstantinides et al238 with permission. Treatment of acute venous thromboembolism with dabigatran or warfarin and pooled analysis, Dabigatran versus warfarin in the treatment of acute venous thromboembolism, Oral rivaroxaban for Japanese patients with symptomatic venous thromboembolism - the J-EINSTEIN DVT and PE program [published correction appears in, Systematic review: case-fatality rates of recurrent venous thromboembolism and major bleeding events among patients treated for venous thromboembolism, Real-world medical cost avoidance when new oral anticoagulants are used versus warfarin for venous thromboembolism in the United States, Evaluation of medical costs associated with use of new oral anticoagulants compared with standard therapy among venous thromboembolism patients, Pulmonary embolism inpatients treated with rivaroxaban had shorter hospital stays and lower costs compared with warfarin, Rivaroxaban versus heparin bridging to warfarin therapy: impact on hospital length of stay and treatment costs for low-risk patients with pulmonary embolism, A direct oral anticoagulant as a cost effective alternative to warfarin for treatment of provoked venous thrombosis, Cost-effectiveness analysis of treatment of venous thromboembolism with rivaroxaban compared with combined low molecular weight heparin/vitamin K antagonist, Cost-effectiveness of rivaroxaban in the treatment of venous thromboembolism in Spain, Pharmacoeconomics - Spanish Research Articles, The cost-utility of dabigatran etexilate compared with warfarin in treatment and extended anticoagulation of acute VTE in the UK, Cost-effectiveness of apixaban versus other oral anticoagulants for the initial treatment of venous thromboembolism and prevention of recurrence, A pharmacoeconomic study of traditional anticoagulation versus direct oral anticoagulation for the treatment of venous thromboembolism in the emergency department, Cost-effectiveness of rivaroxaban compared with enoxaparin plus a vitamin K antagonist for the treatment of venous thromboembolism, Cost effectiveness of rivaroxaban versus low molecular weight heparin and vitamin K antagonists for the treatment of deep-vein thrombosis in the Belgian healthcare setting, Cost-effectiveness of edoxaban for the treatment of venous thromboembolism based on the Hokusai-VTE study, Clinical and economic benefits of extended treatment with apixaban for the treatment and prevention of recurrent venous thromboembolism in Canada, Cost-effectiveness of new oral anticoagulants in the treatment and secondary prevention of venous thromboembolism, Economic analysis of rivaroxaban for the treatment and long-term prevention of venous thromboembolism in Portugal, Cost-effectiveness of rivaroxaban versus warfarin anticoagulation for the prevention of recurrent venous thromboembolism: a U.S. perspective, Dabigatran for the treatment and secondary prevention of venous thromboembolism; a cost-effectiveness analysis for the Netherlands, American Society of Hematology 2018 guidelines for management of venous thromboembolism: optimal management of anticoagulation therapy, Drug therapy in anticoagulation: which drug for which patient [published correction appears in, Catheter-directed thrombolysis (intrathrombus injection) in treatment of deep venous thrombosis: a systematic review, Catheter-directed thrombolysis in the treatment of iliofemoral venous thrombosis. It aims to support quick diagnosis and effective treatment for people who develop deep vein thrombosis (DVT) or pulmonary embolism (PE). Results of a randomized trial, Low dose systemic thrombolytic therapy for treatment of deep venous thrombosis, Pharmacomechanical catheter-directed thrombolysis for deep-vein thrombosis, Multicenter pilot study of the efficacy and safety of systemic rt-PA administration in the treatment of deep vein thrombosis of the lower extremities and/or pelvis, Comparison of therapeutic efficacy of anticoagulation and its combination with catheter-directed thrombolysis for deep venous thrombosis of lower extremities [in Chinese], The post-thrombotic syndrome: incidence and prognostic value of non-invasive venous examinations in a six-year follow-up study, Extended Low-intensity Anticoagulation for Thrombo-embolism (ELATE) Investigators, Predictors of the post-thrombotic syndrome during long-term treatment of proximal deep vein thrombosis, Thrombolysis vs heparin in the treatment of pulmonary embolism: a clinical outcome-based meta-analysis, Thrombolytic therapy for the treatment of acute pulmonary embolism, Thrombolytic therapy of pulmonary embolism: a comprehensive review of current evidence, Safety of catheter-directed thrombolysis for massive and submassive pulmonary embolism: results of a multicenter registry and meta-analysis, Systematic review and meta-analysis for thrombolysis treatment in patients with acute submassive pulmonary embolism, Efficacy of thrombolytic agents in the treatment of pulmonary embolism, Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis, Thrombolysis versus anticoagulation for the initial treatment of moderate pulmonary embolism: a meta-analysis of randomized controlled trials, Advancements in catheter-directed ultrasound-accelerated thrombolysis, Thrombolysis for acute intermediate-risk pulmonary embolism: a meta-analysis, Thrombolytic therapy for pulmonary embolism, When should we thrombolyse patients with pulmonary embolism? They do not, however, replace the careful consideration of the specific clinical circumstances For each guideline question, the McMaster GRADE Centre prepared a GRADE EtD framework, using the GRADEpro Guideline Development Tool (www.gradepro.org). Catheter-directed thrombolysis might increase the risk of PTS (RR, 2.59; 95% CI, 1.42-4.74; ARR, 223 more per 1000 patients; 95% CI, 76 more to 369 more; very-low-certainty evidence). The outcomes were measured in both groups immediately at the end of the extended-duration treatment. However, estimates of the bleeding rate associated with catheter-directed thrombolysis are very imprecise because of the paucity of quality studies and the diversity of methods used. The purpose of this guideline is to provide evidence-based recommendations about the treatment of DVT and PE for patients without cancer. 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